Emerging viral diseases and infectious disease risks

New pathogens and antimicrobial-resistant forms of older pathogens continue to emerge, some with the potential for rapid, global spread and high morbidity and mortality. Pathogens can emerge either through introduction into a new population or when the interaction with the vector changes; emergence is also influenced by microbiological adaptation and change, global travel patterns, domestic […]

Management of COVID-19-associated coagulopathy in persons with haemophilia

The SARS-CoV-2 coronavirus-induced infection (COVID-19) can be associated with a coagulopathy mainly responsible for pulmonary microvasculature thrombosis and systemic thromboembolic manifestations. The pathophysiology and management of the COVID-19 coagulopathy are likely more complex in patients with inherited bleeding diseases such as haemophilia. These individuals might indeed present with both bleeding and thrombotic complications and require […]

Epidemiological characteristics of human prion diseases

In the absence of specific therapies for human prion diseases, which are frequently associated with neurodegenerative disorders with fatal outcome, only an active surveillance can be used to monitor and prevent the transmission of such diseases. For this reason, starting from 1993, surveillance systems have been established in many countries. Moreover, there is urgent need […]

The SISET (Italian Society of Internal Medicine provides some practical information for patients with thrombosis and serious bleeding diseases in case of COVID-19 vaccination

Patients on oral anticoagulant treatment and patients with severe bleeding diseases   People being treated with anticoagulant therapy and patients with bleeding disorders have a generic contraindication to intramuscular injections due to the risk of hematoma.   However, anticoagulant therapy is in most cases indicated for diseases that increase the risk of contracting the COVID-19 […]

Target joint resolution in patients with haemophilia A receiving long‐term prophylaxis with BAY 94‐9027

BAY 94‐9027 (damoctocog alfa pegol; Jivi®; Bayer AG, Germany) is an extended half‐life B‐domain–deleted, site‐specifically PEGylated recombinant FVIII. Due to its prolonged half‐life, BAY 94‐9027 has the potential to maintain FVIII at a higher haemostatic level for longer periods versus standard‐acting agents.This longer half‐life also allows less frequent dosing, which in turn could help to […]