Resolution by deep sequencing of a dual hepatitis E virus infection transmitted via blood components

Hepatitis E virus (HEV) is a zoonotic infection, with consumption of processed pork products thought to be the major route of transmission in England. The clinical features of HEV infection range from asymptomatic infection to mild hepatitis to fulminant liver failure. Persistent, chronic hepatitis is increasingly recognized in immunocompromised patients. Infection via HEV-containing blood components […]

Multiple HBV transfusion transmissions from undetected occult infections: revising the minimal infectious dose

Hepatitis B remains a global major public health issue and a viral infection transmissible by transfusion. The risk of HBV transfusion transmitted infection has been reduced by the selection of donors; the continuous improvement of serological assays to detect the HBV surface antigen (HBsAg); the implementation of anti-HBc screening for antibodies against the HBV core […]

Epidemiological characteristics of human prion diseases

In the absence of specific therapies for human prion diseases, which are frequently associated with neurodegenerative disorders with fatal outcome, only an active surveillance can be used to monitor and prevent the transmission of such diseases. For this reason, starting from 1993, surveillance systems have been established in many countries. Moreover, there is urgent need […]

Buffy coat-derived platelets cryopreserved using a new method: results from a pivotal clinical trial on thrombocytopenic patients with acute leukaemia

The administration of cryopreserved platelets (PLTs) may overcome the limits of platelet shortage and availability, especially during some seasons or in specific contexts like rural areas. After in vitro validation studies, ad hoc prepared buffy coat-derived pooled platelet concentrates (BC-PLTs), treated with dimethyl sulphoxide (DMSO) and cryopreserved (CRY BC-PLTs) at -80°C with a modified Valeri […]

Comorbidities in hemophilia not related to hemophilia and therapeutic prescription concerns

The longest life expectancy makes hemophiliacs susceptible to diseases not related to haemophilia and belonging to the general population as cerebro-cardiovascular pathologies and malignacies. Predictable is also that the younger patients, children and adolescents, suffer from disorders caused by well-being: obesity, metabolic syndrome, abnormal glucose tolerance. In severe elderly hemophiliacs chronic arthropathy is the most […]