New physiotherapy concepts in hemophilia
Until the ’70s, hemophiliacs did not have great means and opportunities to improve the quality of life, they lived in a voluntary “segregation” due to a progressive disability, lacking therapeutic and rehabilitative supports properly for recovering physical activity . Subsequently, replacement therapy was developed with concentrates of the coagulation factors of which they were deficient […]
Physical exercise and rehabilitation in hemophilia
Physical exercise Physical exercise in patients with hemophilia (PWH) currently is used to heal faster after bleeding and to restore muscle-joint function in subjects with chronic arthropathy. Aquatic, stretching, proprioceptive and aerobic exercises are the most usual in PWH A and B of any severity. A Cochraine Database Systematic Review published in 2016 analyzed randomized […]
Bleeding and liver transplantation outcomes in haemophilia
Abstract BACKGROUND: Hepatitis C is the major cause of end-stage liver disease and the major indication for orthotopic liver transplantation (OLTx) in individuals with haemophilia. AIM: To assess the epidemiology and outcomes of OLTx in U.S. haemophilia patients. METHODS: We investigated haemophilia liver transplant recipients between 1993 and 2012, using the Nationwide Inpatient Sample, identified […]
Early start of the West Nile fever transmission season 2018 in Europe
In Europe, surveillance indicates that the 2018 West Nile fever transmission season started earlier than in previous years and with a steeper increase of locally-acquired human infections. Between 2014 and 2017, European Union/European Economic Area (EU/EEA) and EU enlargement countries notified five to 25 cases in weeks 25 to 31 compared with 168 cases in […]
An early start of West Nile virus seasonal transmission: the added value of One Health surveillance in detecting early circulation and triggering timely response in Italy, June to July 2018.
Abstract In Italy, the 2018 West Nile virus transmission season started early with a high number of cases reported. One-Health surveillance, within the Italian West Nile national preparedness and response plan, detected viral circulation 9 days before symptom-onset of the first confirmed human case; triggering timely implementation of blood and transplant safety measures. This is […]
Occult HCV Infection: The Current State of Knowledge
With a clinical history of approximately 11 years, occult HCV infection can be considered an occult type of CHC. Evidences suggest that considering OCI in these high-risk groups seems to be necessary. We suggest that alternative diagnostic tests should be applied and that there is a need for the participation of all countries to determine the epidemiology of […]
Viral metagenomics and blood safety
The characterization of the human blood-associated viral community (also called blood virome) is essential for epidemiological surveillance and to anticipate new potential threats for blood transfusion safety. Currently, the risk of blood-borne agent transmission of well-known viruses (HBV, HCV, HIV and HTLV) can be considered as under control in high-resource countries. However, other viruses unknown […]
18 November 2019
Resolution by deep sequencing of a dual hepatitis E virus infection transmitted via blood components
Hepatitis E virus (HEV) is a zoonotic infection, with consumption of processed pork products thought to be the major route of transmission in England. The clinical features of HEV infection range from asymptomatic infection to mild hepatitis to fulminant liver failure. Persistent, chronic hepatitis is increasingly recognized in immunocompromised patients. Infection via HEV-containing blood components […]
13 February 2019
Multiple HBV transfusion transmissions from undetected occult infections: revising the minimal infectious dose
Hepatitis B remains a global major public health issue and a viral infection transmissible by transfusion. The risk of HBV transfusion transmitted infection has been reduced by the selection of donors; the continuous improvement of serological assays to detect the HBV surface antigen (HBsAg); the implementation of anti-HBc screening for antibodies against the HBV core […]
17 January 2018
Epidemiological characteristics of human prion diseases
In the absence of specific therapies for human prion diseases, which are frequently associated with neurodegenerative disorders with fatal outcome, only an active surveillance can be used to monitor and prevent the transmission of such diseases. For this reason, starting from 1993, surveillance systems have been established in many countries. Moreover, there is urgent need […]
20 November 2019
Buffy coat-derived platelets cryopreserved using a new method: results from a pivotal clinical trial on thrombocytopenic patients with acute leukaemia
The administration of cryopreserved platelets (PLTs) may overcome the limits of platelet shortage and availability, especially during some seasons or in specific contexts like rural areas. After in vitro validation studies, ad hoc prepared buffy coat-derived pooled platelet concentrates (BC-PLTs), treated with dimethyl sulphoxide (DMSO) and cryopreserved (CRY BC-PLTs) at -80°C with a modified Valeri […]
16 October 2019
Comorbidities in hemophilia not related to hemophilia and therapeutic prescription concerns
The longest life expectancy makes hemophiliacs susceptible to diseases not related to haemophilia and belonging to the general population as cerebro-cardiovascular pathologies and malignacies. Predictable is also that the younger patients, children and adolescents, suffer from disorders caused by well-being: obesity, metabolic syndrome, abnormal glucose tolerance. In severe elderly hemophiliacs chronic arthropathy is the most […]